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Current Research
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Systems Biology
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The Mammalian Functional Genomics
Centre (MFGC) at the Manitoba Institute
of Cell Biology and University of Manitoba
currently operates several large-scale
ES cell mutagenesis programs.
The centre’s Director is working on analyzing
the genetic factors which play a
role in leukemia. His technique of disrupting
the genes in mouse embryonic stem
cells and observing the results was key to
understanding how different suspected
genes affected the progression of the disease.
Having demonstrated the strengths
of using this targeted animal model for
gene-based disease research, the director
and the MFGC are now involved in generating
a mouse cell library that will contain
mutations in every gene in the mouse
genome. |
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This project has been specifically identified
as the next most important step following
the Human Genome Project. It will
advance the understanding of how the sequence
of letters (our DNA) translates into
gene function, providing a living blueprint
of instruction and design. This library will
be freely available to all biomedical researchers,
and will significantly impact
biomedical disease-focus research programs
and biotech companies in Canada.
The programs rely on genome-wide blast
analysis of tens of thousands of sequence
tags per project query. The WestGrid infrastructure
in conjunction with MRnet
provides researchers with the much needed
capacity to run the blast search programs.
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